Industry 4.0: Redefining manufacturing operations beyond factory’s four walls after COVID-19

The technologies associated to Industry 4.0 were transforming manufacturer’s operation before the pandemic. Now, adoption is diverging what we have and what we don’t have, be it technology or infrastructure. Mapping between these two is really a big task. Even in part of the World where the effects of COVID-19 have started to retrocede, executives are continuously facing new pressure day by day; they are adopting new strategies to combat the newer emerging problems. In a recent, according to the McKinsey’s survey in South-Asian countries, sudden material shortage was a common issue along with exponentially decrement of demands and worker unavailability but industry leaders have been implementing Industry 4.0 solutions for immediate responding to the crisis.

Few basic tools of Industry 4.0 to accelerate the transformation are connectivity, advanced analytics, automation and advanced manufacturing technologies which were there before the pandemic. These tools have helped manufacturing sectors to gain momentum before the pandemic by transforming their operations. Transformation is ranging from production efficiency to product customization, some newer strategies have been implemented that results faster market-movement, service effectiveness and new business model creation. These four foundational technologies have been applied as an integral part of Industry 4.0 technologies[vc_row][vc_column][vc_single_image image=”8212″ img_size=”full” alignment=”center”][vc_column_text]

Source: www.McKinsey.com

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All the big players in the market are using digital platform based technologies for securing better position compared to their competitors. As companies think about resuming operations by building the muscle to fight with future crisis using digital technologies only, 91 percent heavy machinery companies have invested something for digitalization to follow the stiffer slope of growth in future. Industries need to develop resilience to deal with the temporary crisis at this moment. There are three possible technological transformations to be adopted by the industries to emerge from this low-land.

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But there are many Industry 4.0 technologies which can be implemented without major investments.

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Source: www.McKinsey.com

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Artificial Intelligence in Economics

  • What is Artificial Intelligence?

The main feature of economic theories is that they try to eliminate the effects of uncertainties by attempting to bring the future to the present. Artificial intelligence (AI) is the intelligence which is derived in a non-human manner out of synergy of working of individual units towards a specific direction with a defined objective, for example, in a room where many people are meditating out of their own choice without forcing others, a vibe is generated and motivates a newcomer to sit in meditation spontaneously. This vibe does not belong to any body in particular, but benefits everybody in performing the meditation activity smoothly. It is AI.

  • AI in Price Discovery in Real Sector

The determination of selling price in a market where innumerable transactions are happening with respect to a particular product be it a potato in the vegetable market or a share of some company in a stock exchange is an AI process. A process similar to the auctioning in the vegetable markets in India in the early morning is codified in the software programmes and is run on the trading platform of the exchange houses to track the tatonnement of bids and offers over a scrip.

  • AI in General Equilibrium

The earlier circular reference function in the spreadsheet helping simultaneous determination of output and interest rate together in real and monetary sectors has grown into the AI process where it is possible to determine volume and prices not only in all output markets but also at the same time in all input markets delivering a general equilibrium at a much-reduced time frame. 

  • AI, Big Data, Data Science, Analytics, Machine Learning and Algorithm

There is hardly any water tight compartmentalization among big data, data science, algorithm, analytics, machine learning and AI. We can say that one works with the others. Let us consider the process of forecasting admission or demand for treatment in a private hospital for some specific disease. If information are collected from all patients or their relatives regarding what prompted them to go to a particular private hospital in presence of many other hospitals offering the same treatment and thus such data are collected from all patients or their relatives of all private hospitals offering the said treatment that enormous data can be structured by big data process and then modelling can be conducted by analytics procedure.

Once the demand function is framed, suitable apps in android and other operating systems are developed as the channels of contacts between the points of demand and supply. In connection with microeconomics many of the apps like amazon and iiomart are playing the roles of online markets of final products in the real sector. The markets of the factors of production like capital are those like YONO SBI and NSE mobile and those like Naukri.com are for labour. 

Algorithm can help framing the demand function and then AI may conduct the forecasting process.

  • AI in Financial Sector

In financial economics there is widespread use of AI in making decisions of trading in financial securities like stocks and bonds based on prediction of their prices and also in making decisions of entering interest rate derivative contracts with speculative or hedging motives based on prediction of benchmark interest rates like LIBOR (short term) and 10-year government security yield (long term).  Algorithmic trading, automated trading etc are now common vocabularies in financial literature. The most spectacular contribution of AI is toward indicating a tail loss in the value at risk that was not available before the subprime crisis. That way AI can be useful in preventing systemic crisis.

  • AI to Prevent Loan Default

Application of big data to the details of loan defaulters of the all the banks and application of AI in detection of moral hazard underlying certain lending-borrowing decisions can provide an earlier signal about a prospective default.

Above all are about use of AI relating to profit-making or utility-maximizing decisions generally in the arena of microeconomics, financial economics, industrial economics and game theory.

  • Socio-economic Applications of AI

Relating to macroeconomics and development economics, big data, data science and AI can be useful, e.g. in predicting (i) the number of migrant labourers between two regions in urban economics, (ii) the interest losses to governments and the corresponding volumes of funds returned by the target users in public finance, (iii) the volumes of unaccounted transactions in the informal sector and the concerned behaviour of the economic agents involved in those transactions in Indian economy, (iv) loss of incomes of farmers disconnected from the electronic national agricultural market (eNAM) in agricultural economics, (vi) inflation and unemployment in macroeconomics and so on.

  • AI for Economic Research

Theorizing economic behaviour is a major part of economic research. The process of collection of data on economic behaviour has been evolving toward being more and more automated since the ICT (information, communication and technology) revolution. Over last two decades in India the researchers have been finding their hard discs deluged with big data collected through internet portals and electronic payments. Analysis and interpretation of these data using AI ushered in a new age of economic research.

  • Caveat

Unfortunately the Inability to track the use of each and every coin and paper note of a conventional currency or fiat money in an emerging economy causes cavity in the database of transactions in a sizeable informal sector as a result of which application of AI and the associated tools may not be able to yield the desired results in absence of computer literacy, financial inclusion and technology-oriented mindset of the entire population.

#PositiveCorona: Inventions at the face of adversity: electronic gadgets, man’s best friend in combatting the 2020 pandemic

Our world is facing a really grave situation, namely the uncontrollable spread of a never known before virus that Is capable of killing. The situation is at its worst and is reminding us of the World Wars. But as history has always shown, the vivacity and splendor of life always wins over the forces of evil. Accordingly researchers from all over the world are coming up with various efficient solutions to combat this unseen enemy. In such a noble venture science and technology is posing as our best friend. Though this deadly situation has handicapped humankind in various aspects, yet life saving technological creativity and innovation is attaining unprecedented heights in these hard times. Below is presented an overview of a collection of wonderful gadgets that are acting as magic wands in detection and prevention of coronavirus. Several viable solutions are being proposed to combat this spread of pandemic. Among such solutions electronic device based equipments are playing a major role. Several such acceptable and cost effective solutions are being proposed by various research groups from all over the world.

Of the several detection devices, the following stand out due to their efficiency and accuracy.

  1. Real time in situ detection of COVID-19 viruses may be possible using quantum tunneling based nanogap sensors. Such quantum tunneling based detection is expected to be 1000 times more accurate than thermal or other detection methods. The sensitivity of such detectors are expected to be unprecedented till date.
  2. For successfully combating Sars2 Covid 19 viruses proper comprehension of their behavioral evolution is necessary. Researchers have proposed polymide nano fibre based technologies for nano scale capture of aersols.
  3. Deactivation of virus using copper is a traditional method. Yet the process is necessarily a slow one. However, researchers have come up with new promising technology. And chemical free inactivation of Covid 19 virus has been made possible. Such technology may be used in N 95 masks as well. Copper is being used in the form of electroactive nano particles. The technology can be used to disinfect Covid 19 virus present in the atmosphere in a room or cabin etc.
  4. Other technologies such as the use of disinfecting nanobubbles have also come up to combat this pandemic situation.  Such nanobubble based disinfecting is even suitable for hospital cubicles.

Next a review of recently invented gadgets and devices for arming humankind against coronavirus is provided.

  1. Steve Brooks, a London based inventor, has come up with ‘hygiene hook’ which is a device or rather a gadget that enables us to open a door without physically touching it. Moreover the gadget is made up of non porous material and therefore is user friendly and easy to clean. To top this, the gadget is 3D printable as well, therefore, industry level manufacturing is easy and is cost effective.
  2. Multi functional UV sterilizers and wire free chargers have been introduced for our smart phones. Therefore, contamination and disease spreading from our mobile phones, which are not so easy to clean, will no longer pose a threat. Apart from smart phones, gadgets like watch, earphones etc may also be disinfected with the help of this device.
  3. Another important invention is the self cleaning water bottle. This also uses UV protection against contamination and therefore, the users may rest assured that not just Covid 19 viruses but other harmful disease spreading bio elements will also be destroyed from the drinking water present in these bottles. Such bottles are made of 18/8 food grade steel which is heat preventive and rust free. And UV-c light is used for disinfecting the liquid present in the bottle. Further an UV nanotechnology plating is also used.
  4. Several other UV based technologies are playing their part in the fight against Covid 19. Amongst them UV sanitizer bar and UV sterilization box deserve a special mention. Both of them belong to the affordable price range and are expected to be satisfactorily effective in preventing the spread of this harmful virus as well as other possible contaminations. Besides both are lightweight and easily portable.

The sanitizer bar uses UV-c light to sterilize the object or the spot on to which it is focused. It is hardly the size of a television remote and maybe easily got it in once pocket.

The UV sterilization box also uses the same principle of disinfection. But unlike the sterilizer bar, this comes with the chamber that is capable of entirely bathing the product from all directions and therefore complete sanitization is possible. Apart from simply sanitizing, these sophisticated gadgets also offer luxuries such as added aromatherapy chambers that in turn would result in a pleasing fragrance to be bestowed on the sanitized product. Moreover, almost all variations of UV sanitization chambers are equipped with extra ozone disinfection.

  1. Another important invention is the mini oximeter. This is non invasive and easy to use. This monitors the oxygen level in human body and reverts if some abnormality is noticed. This is also an optoelectronic gadget that sense beams of light belonging to various frequencies through the users finger in order to sense pulse oxygen content.
  2. Our country is not behind as well. Our engineers end inventors have come up with several valuable technological weapons to fight back this unseen enemy. that includes disinfectant drones, ultraviolet guns, air evacuation pods etc.

Therefore, even in these dark times, we should not lose hope. Every cloud has a silver lining and together we will try our best and overcome this killer virus, equipped with our wonderful inventions and ingenious technologies. Let’s keep safe.

Digital Adda: A Paradigm Shift Among The Bengali Middle Class

The term ‘adda’ (as defined by Dipesh Chakraborty) signifies ‘the practice of get together of friends for long, informal and un-rigorous conversations’. Adda whch was historically a practice among the middle class Bengali men (Bhadrolok) has also become a practice of middle class Bengali women as well.

Historically, adda as a practice originated since colonial rule with the onset of Coffee Houses in Kolkata by academic elitists followed by baithakkhana(visiting parlour) followed by tea stalls, bus stops, office cafeterias, and mostly in the rawk (the external verandah), the glimpses of which still continue to exist in the traditional lanes of North Kolkata! Neverthless, adda soon became quintessential of Bengali middle class from twentieth century when it transformed from a private to a public venue. The fact that adda was a known practice among Bengali middle class was mainly because it originated among the Bengali middle class men.

Due to the present pandemic situation which has brought forth new norms and practices, another major paradigm shift has mainly been with regard to the change from the physical interaction (adda) to social interaction virtually. However, before the pandemic hit the world, adda over the virtual space used to take place but it became more normalized with the lockdown phase.

Social media which on one hand helps to stay in touch with any closed kin, peer or acquaintance globally, also on the other hand presents notable challenges involved in its access. The present digital adda is mostly prevalent among the upper and middle class since digitization imposes the challenge of digital divide in a Third World country like India! Social media has opened up avenues for the affluent classes of society due to which both en and women irrespective of their age are being able to spend valuable tie with their friends (even if it involves friends from locality- para).

Though the present Unlock 4 of the post-pandemic situation has allowed people to venture out mostly at times of need, yet adda over the virtual space continue to predominate characterized by tinge of laughter and ecstasy related to family affairs and gossip about friends and intimate relations. However, a massive paradigm shift can be noticed from the physical to virtual interaction where physical distancing along with social solidarity can be properly maintained (keeping in mind the pros and cons of social media usage!). After all, Bengali middle class is mostly best in adopting and accommodating to any new norm and practices (with due reverence to other classes). While on one hand, it has been envisioned that adda as a practice in physical space is becoming obsolete, it is also been replaced by social media like WhatsApp, Facebook, Hangout, Telegram. The only hope that Digital Adda continues to exist since adda is one of the defining key characteristic of most Bengali middle class culture without which Bengalis may seem to lose their identity!

Reference:
Saha, Wriddhibrata, Performing Gender in Adda Spaces, Sessional Paper, Pgs 4,9, Retrieved 13-09-2020

New Education Policy 2020: Welfare Economics Perspective of Policy Design

What a policy is

A policy is a plan of actions toward achieving certain goal of any private or public community. Lending policy of a private sector bank is an example of the former whereas education policy is an example of the latter. In this document ‘policy’ will imply public policy. As an example of public policy the New Education Policy will be referred to here.

Why is at all a public policy required?

A public policy is one of the tools in achieving a number of goals, e.g. mitigating socio economic inequality, towards implementing the Directive Principles of State Policy in the Constitution of India.

What is the theoretical underpinning of a public policy?

(a) Failures and attempts to address facts of life: The theory of public policy originated from the failure of all disciplines of study to answer hard questions of life like (i) why this baby is born on a street when that child is born in a golden bed at the same time, and the consequent endeavours to answer the question (ii) what the fate of the street-born baby would be in terms of being a blessing or curse for the society in future?

(b) Welfare Economics: The discipline of Welfare Economics, a specialized part of Microeconomics tries to answer the latter question with the help of the theories of market failure, externalities and internalization of externalities.

(c) Theory of Consumption: In terms of Microeconomics consumption of food, cloth etc by a baby is financed by the guardian. When the child reaches the adult and starts earning, gradually his income increases over and above consumption. When his guardian becomes old his income falls short of consumption, the grown up child can repay the above finance by taking care of the latter during old age.

(d) Theories of Externalities and Market Failure: An individual’s cost of own consumption is a private cost but the cost of other’s consumption is a social cost. Similarly an individual’s benefit derived from a good purchased by him is a private benefit but if he derives benefit from a good purchased by somebody else, it is a social benefit. The differences between social and private costs and between social and private benefits are called externalities. The excess of the social over the private is called positive externality and the vice versa. The inequalities between private and social costs and between private and social benefits are called market failures. Market here means equality between the cost to be incurred for and the benefit to be enjoyed from an additional unit of consumption of a good or a service. By the common parlance ‘market’ used by laymen means the same because in the market a buyer tries to bargain with seller over the price if the buyer feels that the above cost is more than the above benefit and the seller tries for the reverse by demonstrating that the above benefit is more than the above price. At some point of the bargaining process, both the parties strike the equality between the two.    

(e) Internalization of externalities: Market failure can be corrected by arranging equality between social cost and private cost, e.g. punishing an offence and between social benefit and private benefit, e.g. rewarding an act of bravery. The State facilitates the internalization process by providing public goods like police, defence, judiciary and so on.  

(f) Applications of the Theory of Consumption: Homes run by the governments, trusts and religious institutions provide finance for consumption by poor children or orphans.

(g) Application of Externalities and Market Failure: Free goods and services are out of the purview of Economics discipline. Here ‘good’ will mean a good or service available at a price. Every activity involving a good is called a transaction. There are certain activities that lead to market failure and generate externalities. Expenditure by a government or donation by a private party generates positive externalities while taxation, crime etc generate negative externalities.

 A human being has a body and a character. There are prices of physical organs, bones and blood as informed by crime reporters but there are higher prices of character, talent and other mental faculties computed in Human Resource Management. If a criminal provides for consumption of the street-born uncared child in order to derive future benefits toward criminal profession, that child will grow into a source of negative externalities in future. On the other hand if the government or some trust takes care of the child, the result could be expected to take the form of a responsible citizen, a stream of positive externalities in the society. 

Design of National Education Policy 2020 (NEP)

Economists view education increasingly as central to issues of development like productivity, income distribution, employment, and knowledge as an input to production. They offer varying opinions as to whether education is a public good or private good. Despite the aforesaid differences, education whether private or public, aims to provide the educated with the access to the market with higher purchasing power, addition to aggregate demand, expansion of production and rise in national income. 

There are three new dimensions of the NEP over the National Policy of Education 1986 – (i) the digital dimension, (ii) holistic multi disciplinary dimension and (iii) marketing dimension. It revolves around the public good aspect of education. An economist believes that education as a public good has three objectives – expansion, excellence and inclusion; education as institution should build up human capital and education as an input in the production process should contribute to product development, upgrade and innovation. 

Expansion: The NEP encourages expansion of education across arts, disciplines and languages.

Inclusion: The NEP encourages adult education and discourages coaching centres at school level where the poor or those who do not have purchasing power do not have access. It encourages private institutions to offer subsidized or free education and scholarship.

Excellence: The NEP prescribes scholarships to rural meritorious students.

Human Capital: The NEP prescribes enhanced investments in vocational education and multi disciplinary education. High skilled human capital is supposed to facilitate innovation in businesses.

Input in production process: The NEP encourages marketing of Indian Education as a product for sale to foreign students by prescribing such activities in institutions of higher education. 

Conclusion

Failure of public policies to correct market failure through misuse of public goods has given rise to preference of the capable for the private over the public and generation of demand for commercialized services of public good character, e.g. private education, private health, private security etc.

The NEP terms a teacher to be central to the education process but in the private education industry and corporatized institutions, where the faculties and departments are shaped as profit centres, neither does a teacher stick to one institution for long time nor is there is any job security even if he wants to continue and as such there is drainage of institutional knowledge disrupting the human capital formation process. The reason is given below.

The NEP prescribed non-profit governance of private institutions. Materialization of the same is difficult for efficiency reasons. The measure of efficiency differs across sectors and firms over time. In the discipline of Economics, efficiency in a market economy means every factor of production earns its maximum possible remuneration from its best possible use without any wastage and is free to switch to another employer if the ongoing employment is inefficient. In the discipline of Human Resource Management efficiency means the yield of output to the inputs. Accordingly the HR divisions of the private universities design efficiency measure in the name of performance appraisal. In a command economy or in a mixed economy with a public sector of education neither can a factor switch to another employer or nor can his performance appraisal vary over time because the static measure of efficiency that is obtained during the employment process does not change till the stipulated time of retirement. So there is no motivation of either party for information asymmetry. The sovereign guarantee of tenure of a factor in public sector plays the role of job security during the tenure. However that is a source of moral hazard in the public sector but both moral hazard and information asymmetry exist in a private education industry. The temporary or contractual nature of employment in the monopolistically competitive structure of private education industry with the dynamic nature of efficiency measure generates enough motivation for moral hazard and scope for information asymmetry. The above motivation is reflected in the tendency of a factor to auction itself every moment to the best bidding employer. The above scope is reflected in the uncertain future contingencies. As long as factor movement is allowed free, institutional knowledge and specialization cannot build up for research and innovation.

The future will tell how far the NEP is successful in curbing commercialization of education and how the private institutions fulfils the aims of this policy.

Nanomedicine based Therapeutics for Inflammatory Diseases: Possible Strategies on Facing the SARS-CoV-2 (COVID-19)

Introduction

Engineered nanoparticles (NPs) have broad applications in industry and medicine. Recently an era of nanotechnology has coined a new term “nanomedicine” which is the application of nanotechnology in medicine.1 The novelty of nanomedicine encompasses the smart delivery of nanosized (1-100 nm) therapeutic or diagnostic agents selectively to the diseased lesions and specifically elicit pharmacological effects without affecting the healthy cells and tissues. Thus, nanomedicine has been widely acclaimed as potential probes for the treatment, detection, and prevention of various diseases. Recently our world is passing through a perilous situation due to the sudden outburst of Coronavirus disease 2019 (COVID-19) caused by novel severe acute respiratory syndrome called coronavirus 2 (SARS-CoV-2)2. It is the need of an hour to develop novel therapeutics to combat this uncontrolled inflammation caused by the fulminant cytokine storm in recent COVID-19 infections.

Nanomedicine approach for Inflammatory diseases: A possible hope for COVID-19

To begin with an uncontrolled inflammation in COVID-19, we need to have an idea about inflammation which is simply the body’s own defense mechanism to any damage, making it an important part of the healing process.3 However, uncontrolled inflammation directly contributes to the pathogenesis of a diverse array of chronic diseases, such as infectious diseases, cancer, neurodegenerative disease, diabetes, cardiovascular disease, and immunometabolic disorders.4 Recently in the COVID-19 infection, it was observed that the certain cases of COVID-19 infections resulted in death by the propagation of the acute respiratory distress syndrome or ARDS. In ARDS, the lungs fill up with fluid preventing oxygenation and effective delivery of therapeutics through the inhalation route.5 It was observed that some patients suffering from COVID-19 has developed a cytokine storm4-5 i.e. an hyperinflammatory state is developed in their body triggered by viral infections. Today in the existing anti-inflammatory therapy, various steroidal or nonsteroidal anti-inflammatory drugs, corticosteroids have been broadly used for the treatment of different inflammatory diseases, despite having severe side effects.6 Biological therapeutics, such as monoclonal antibodies, cytokines have been used to treat such inflammatory diseases by interfering inflammation-associated molecular profiling and neutralizing disease-specific pro-inflammatory cytokines.7

During the last few years, specifically engineered nanoparticles (NPs) have earned emerging preferences over the use of conventional anti-inflammatory drugs due to their biodegradability, stealth characteristics, low toxicity and specific targeting efficacy with ensured better delivery of therapeutics with reduced side effects.8 Most popularly used NPs are polymeric nanoparticles, hydrogels, solid-lipid nanoparticles, liposomes, protein nanoparticles, metallic nanoparticles and dendrimers.9 A broad range of active moieties including antivirals, biologics, and nucleic acids can be loaded and delivered by these engineered nanocarriers. These nanocarriers have the potential of regulating the expression of pro and inflammatory molecules and targeting inflammatory sensors or macrophages through phagocytosis. These nanocarriers can specifically target to antigen presenting cells (APCs), could be of great value to promote cellular response or immune tolerance thanks to the surface tunability which allows them to passively (through size and surface charge of NPs) or actively (through decorating NPs with target molecules like specific antibodies) target these cells.10 These anti-inflammatory nanomedicines have shown excellent impacts in therapeutic development of rheumatoid arthritis (RA), diabetes, inflammatory bowel disease, asthma and Alzheimer’s disease. Thus, they could be used as potent probes in the treatment of hyper inflammatory COVID-19 infection.8-10 In the treatment of COVID-19, some researchers have already started using these anti-inflammatory nanomedicines to combat the deadly SARS-CoV-2 virus. Various well-known strategies such as the use of repurposed anti-inflammatory drugs (hydroxychloroquine, methotrexate) as the targets for RNA polymerase and the viral S protein with host receptor ACE2 have been applied as the major pathways of therapeutic development. Antibody targeting approach for surface S protein and for pro-inflammatory cytokines (IL-6/IL-6R) is also another popular strategy in the COVID-19 treatment.11-12 The reason for the selection of nanomedicines over conventional drugs was discussed in three main aspects and may be a sturdy way out to control over this COVID-19 pandemic.[vc_row][vc_column][vc_single_image image=”7989″ img_size=”full” alignment=”center”][vc_column_text]

Figure 1. Anti-inflammatory nanomedicines: strategies and targets.8

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Engineered nanocarrier as an alternative to conventional therapeutics

The major drawback of conventionally used anti-inflammatory drugs such as methotrexate (MTX), Curcumin (Cur) is their very low tolerable payloads. In order to solve this problem, in the treatment of RA, poly (lactic-co-glycolic acid) were integrated with gold (Au) nanoparticles and the RA targeting was achieved by tethering with arginine-glycine-aspartic acid (RGD) peptide. This nano vehicle was loaded with the anti-rheumatic drug MTX which displayed increased efficacy and reduced toxicity in CIA mice when compared to conventional treatments using MTX only.13 In addition, solid-lipid nanoparticles coated with CD44 receptor targeting hyaluronic acid (HA) has showed a significant improvement in collagen induced RA due to the selective accumulation of NPs in the inflamed tissues of mice.14 In inflammatory disease bowel syndrome, curcumin, a well-known anti-inflammatory drug is nanosized using some pH sensitive polymers to improve its bioavailability as well as targetability to the specified sites.14 The systematic circulation instability and the prerequisite of their intracellular delivery is the well-known limitation of nucleic acid (e.g., RNAi) drug candidates. Recently, a number of siRNA-encapsulated lipid-based nanoparticles (LNPs) were reported for the treatment of intractable diseases such as cancer, viral infection, inflammatory neurological disorder, and genetic diseases.15

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Figure 2. Nanomedicine strategies for COVID-19 therapeutics development.12

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Chemical engineering to therapeutics

Conventional drug molecules are altered to improve their compatibility with a particular class or type of nanocarriers, rendering this a more generic approach for drug candidates with similar physicochemical properties. The potent anti-inflammatory corticosteroid dexamethasone (Dex) nanoformulations have already been successfully used in different inflammatory diseases including rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, liver fibrosis, wound healing and cancer. Most of these works have shown pH sensitive polymeric nanomedicines where Dex was attached to these polymers using biodegradable spacer molecules. This well-known anti-inflammatory Dex is extensively used in the recovery trail of COVID-19 treatments where patients are administered with the Dex daily showing the reduction in of COVID-19-related deaths by 35% in patients on the intensive care unit (ICU).16 Similarly, in another report, instead of using conventional drug hydroxy chloroquine, cholesterol-modified hydroxychloroquine (Cho-HCQ) loaded liposomes with reducing toxicity also inhibited the proliferation of rat lung fibroblasts, thereby, reducing pulmonary fibrosis.17 The proinflammatory cytokine IL-6 available from the cytokine storm of critically ill COVID-19 patients can be specifically targeted using anti-IL-6 antibody tocilizumab which has been an established therapy in the treatment of RA.18 Thus, similar to RA, these hyaluronate-gold nanoparticle entrapped Tocilizumab can be targeted to COVID-19 patients and may be an effective therapeutic strategy to fight the deadly virus.

Nanomedicine for Combination Drug Therapeutics.

Combination drug therapy is another accepted strategy for the treatment of COVID-19. There are several reports available on these nanoparticles modified hydrophobic/hydrophobic drug delivery for inflammatory diseases which can be potentially useful for this corona virus treatment. A nanosuspension of lipid nanoparticles (LNPs) loaded with three antiviral drugs (two hydrophobic: lopinavir and ritonavir and one hydrophilic: tenofovir) has been formulated to overcome the lymph node drug insufficiency of the oral combination of these drugs.19 In addition to the repurposed drug therapy, Patrick Couvreur et al. has also fabricated a multifunctional nanomedicine using bioconjugation strategy of adenosine to squalene with further formulation with tocopherol.20 It was shown that this nano formulation can target inflamed tissues in multiple murine models of inflammation for adenosine receptor activation and antioxidant action.

Conclusion

Advances in bio/nanotechnology and advanced nano/manufacturing coupled with open reporting and data sharing lay the foundation for rapid development of innovative therapeutic/vaccine technologies to make an impact during the COVID-19 pandemic. To date, there are no specific approved drugs for treating SARS-CoV-2, and vaccines are under clinical trials. The devastating effect of COVID-19 over the world may serve as an impetus for the scientific community, funding bodies, and stakeholders to commit more focused efforts toward development of platform technologies that encourage the preparedness for future pandemics. Along with rest of the world, in our country, some of the companies like Hetero drugs, Cipla Ltd, Zydus Cadila have started manufacturing and marketing some of the repurposed anti-inflammatory or anti-viral drugs remdesivir and hydroxychloroquine for the treatment of COVID-19 patients. All efforts are welcome to combat the virus, and nanotech-based approaches would bring a new perspective to conventional medicine for the inhibition of virus internalization or treatment. Certainly, in this era of advanced nanoscience, nanotechnology could play a frontline role in tackling this outbreak.

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  17. Liu, J. Ren, Z. He, et al. Sci. Rep. 2017, 7, 10737.
  18. Lee, M.Y. Lee, et al. ACS Nano. 2014, 8, 4790.
  19. C. Kraft, L. A. McConnachie, et al. J. Control. Rel. 2018, 275, 229−241.
  20. Dormont, R. Brusini, C. Cailleau et al. Sci. Adv. 2020, 6, 5466.

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How to Rank Courses on Financial Risk Management

Relevant to the following courses of the PG programme M.Sc. in Quantitative Finance

  • Credit Risk Management
  • Market Risk Management

Financial risk means unsystemic risk e.g. credit risk and systemic risk e.g. market risk.  Generally credit risk management and market risk management are covered in post graduate programmes. A student having learnt management of these two risks can seek employment in commercial banks, investment banks, development banks, development funding institutions, non-bank financial companies, broking houses, corporate group treasuries, regulatory institutions, self regulatory institutions etc.

Ranking of a course is inclusive in ranking of a university and its programmes. Ranking of a university means comparing a degree programme or other programmes like diploma programmes and certificate courses offered by a university with the same or similar programme offered by other universities. Ranking of a programme is by and large correlated with overall ranking of a university.

Ranking is an outcome of rating. Rating is a symbol or a symbolic phrase with an underlying numerical score. The aforesaid numerical score can be an average of several other scores, just like CGPA is the average of the grade points obtained in different subjects but unlike CGPA, which is the simple average in a flat structure, the average score in the case of rating is a weighted average of the scores of several categories e.g. parameters, areas, criteria, pillars, and indicators in a pyramidal structure, where each of these categories has a number of underlying sub-categories and the individual score of a category is again the weighted average of the underlying sub-categories. In the case of rating of universities, first the universities are classified in groups in terms of (a) ownership like government, private sponsor or trust or public-private partnership, (b) source of funds, i.e. whether funded by government, private sponsorship or self financing and (c) the mode of establishment, i.e. whether by a state legislature, by the central legislature/parliament or by a declaration under section 3 of UGC Act as deemed university.  Generally there is a positive correlation between (a) and (b), e.g. a university without a private sponsor has access to grants from the government. These provisions are mentioned in the relevant Act.

There are several ranking agencies in India and abroad. In India there are two categories of such agencies: (a) public and (b) private. Public agencies are (i) NAAC and (ii) NIRF.

(i) National Assessment and Accreditation Council (NAAC) – NAAC is a national accreditation agency established by the Government of India in 1994 as a part of University Grants Commission with a view to taking care of quality and relevance of higher education in India offered by universities, colleges and autonomous institutions. Based on seven criteria and several indicators under each criterion totaling to thirty four in number, it awards grades in the combinations of the letters ‘A’, ‘B’ and ‘C’, something similar to the way the credit rating agencies like Standard and Poor, Moody’s and Fitch rate the sovereigns, firms and the financial securities issued by these entities. Curricula of the courses of the programmes offered by the universities find their places in Criterion I of NAAC grading.

(ii) National Institutional Ranking Framework (NIRF) – NIRF is launched in 2015 in order to upgrade the higher education institutions to world ranking. The ranking originates from scores of five parameters and the metrices under each of these parameters totaling to sixteen. Curricula of the courses of the programmes offered by the universities do not find direct places here.

(b) There are a couple of private agencies ranking Indian universities. The notable among them are

(i) Outlook-icare: It ranks the universities and other higher education institutions  based on total five hundred score consisting of hundred for each of the five parameters where each parameter has two underlying indicators. Curricula of the courses of the programmes offered by the universities do not find direct places here.

(ii) Times Higher Education: It ranks the universities in different countries based on the percentage scores of five areas where each area has underlying multiple performance indicators totaling to thirteen. Curricula of the courses of the programmes offered by the universities do not find direct places here.

(iii) India Today: It covers four areas in the ranking process. The area named ‘Quality of Academic Input’ reflects directly on the curriculum of a course.

(iv) Quacquarelli Symonds (QS): It ranks universities based on reputation and research.  

The parameters/areas and the underlying indicators used in the methodologies of ranking universities by the private agencies seem to be closer to NIRF’s methodology than to NAAC’s. While the curriculum of a university finds place explicitly in the methodology of NAAC, the value of the curriculum reflects on the objectives and outcomes in the methodologies of NIRF and private agencies generally. The objectives of a course are connected to the value of the course embedded in the quality of the teacher in terms of her research, citations and relevance to the industry or contemporary world and mode of delivery, i.e. communication, clarity, quality of study material and doubt clearing. The outcomes appear in the form of the learner’s employability or competitiveness for higher studies.

Hence in line with NIRF, we can design as follows the following rating methodology of the courses on financial risk management as part of the PG programme offered by a school/faculty of a university

  1. Teaching Learning Resources (100%)
  • Teacher /Student ratio (25%)
  • Teacher’s qualification and experience in financial risk and related topics (35%)
  • Library & other academic facilities (40%)
  1. Research on financial risk (100%)
  • Publications on financial risks (45%)
  • Citations (45%)
  • IPR/Patent/software/exel format design (10%)
  1. Course outcome (100%)
  • Student performance in university examination (50%)
  • Student performance in examination/interview for recruitment or higher studies (50%)
  1. Inclusion (100%)
  • Education to non-regular candidates like working executives (25%)
  • Representation of students from other states/countries (25%)
  • Representation of genders in both of teachers and students (25%)
  • Representation of economically and socially weaker students (25%)
  1. Student perception (100%)
  • Syllabus coverage (20%)
  • Class interaction (20%)
  • Clarity of information (20%)
  • Availability of study material (20%)
  • Level of practical exercise (20%)

So we can rate a course out of five hundred points in terms of five parameters and seventeen indicators relevant to the nature of the topics in the course

 

#BiotechnologyNext :Phytoremediation: Cleaner in a Greener way

Student contributors: Tanusree Paul & Subhangi Mahapatra (B.Sc. Biotechnology, SEM-VI)

In the race of development, anthropogenic activities result in contaminated soil by the accumulation of heavy metals and pose a threat to human health and the surrounding ecosystem. Certain chemical pollutants remain in the environment for a prolonged period. Several remediation techniques for heavy metals from contaminated soil-water are expensive, time-consuming, and environmentally destructive. In recent years, researchers have developed a promising and innovative technology termed as phytoremediation for remediation of sites with inorganic and organic pollutants. It is a plant-based remediation technology that uses green plants to stabilize and reduce contamination in soil, sludge, sediments, surface water, and groundwater. Phytoremediation plants must possess few specific qualities like (1) high biomass, (2) rapid growth, (3) deep and hairy root system, and (4) high bioaccumulation coefficient. Some plants can grow on soils with high levels of metals and can accumulate massive amounts of the indigenous metals in their tissues; those are termed as “hyperaccumulators”. Phytoremediation technique comprises five different strategies, those are-

  1. Phytoextraction, which removes metals and organics from the soil by accumulating them in the biomass of plants. Example, Indian mustard.
  2. Phytodegradation, which uses plants to uptake, store, and degrades organic pollutants. Example, hybrid poplar
  3. Rhizofiltration, which involves the removal of pollutants from aqueous sources by plant roots. Example, sunflower
  4. Phytostabilization reduces the bioavailability and mobility of pollutants by immobilizing of binding them to the soil matrix. Example- Various species of grass, such as red fescue
  5. Phytovolatilization utilizes green plants to take pollutants from the growth matrix, transform them, and release them into the atmosphere. e.g.- poplar trees.

Factors Affecting the Uptake Mechanisms

The different  factors that can affect a plant’s uptake mechanism of heavy metals are

  • Plant species
  • Properties of medium
  • The root zone
  • Vegetative uptake
  • Bioavailability of the metals
  • Addition of chelating agents

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Remediation of Inorganic Contaminants

The remediation of contamination with an inorganic contaminant must either physically remove the contaminant from the system by removing the biomass or convert it into a biologically inert form.

Remediation of organic contaminants

Organic pollutants are xenobiotics to the soil. Soil pollution with organic contaminants is one of the most obstinate environmental problems today. Among the various organic contaminants, persistent organic pollutants (POPs) are the most common due to their long-term persistence, bioaccumulation, and high toxicity. Polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), total petroleum hydrocarbons (TPHs), and pesticides are the most common groups of POPs existing in contaminated soils. They cause significant negative effects on the environment because of their high toxicity, mutagenicity, carcinogenicity. One patented process uses a carrot to absorb dichlorodiphenyltrichloroethane. The carrots are then harvested, solar-dried, and incinerated to abolish the contaminant. Another method for direct extraction of an organic contaminant from the soil by using plants is root accumulation, xylem translocation, and subsequent volatilization from leaf surfaces.

Role of biotechnology in phytoremediation

Phytoremediation is still at an early stage of development. Plant biotechnological approaches have played an important role in phytoremediation. An ideal phytoremediator would be highly tolerant of the pollutants, capable of metal uptake and accumulation, also able to either concentrate or degrade the pollutants in the biomass at high levels. Plants, that can translocate metals from roots to shoots at high rates are more effective hyperaccumulators. Since most of the metal hyperaccumulators have low biomass and are slow-growing,  biotechnology allows transferring hyperaccumulator phenotypes into high biomass, fast-growing plants that can be highly effective in phytoextraction. Excess production of hormones in hyperaccumulators can alter their biomass production. Although the use of biotechnology in the development of the transgenic plant with the improved potentiality for efficient sustainable bioremediation is highly promising. Several researchers devised transgenic plants to reduce some of the constraints of metal phytoremediation, few transgenic plants are developed to tolerate a high level of accumulated cadmium and lead.  Transgenic plants are produced by genetic engineering techniques whose DNA is modified. In the laboratory, genetically engineered plants are produced by altering the genetic-character, usually by adding one or more genes of a plant’s genome. Enhanced gibberellin’s production in the transgenic plant was shown to promote biomass production and growth. Genetic engineering is a powerful method that improves the capabilities of natural phytoremediation, or it introduces new capabilities into plants. For example, genes encoding a nitroreductase from a bacterium were inserted into tobacco resistance to the toxic effects of TNT. Also with the help of biotechnology, it is possible to improve the gene expression for maximum resistance. Certain plants show increased resistance under the presence of certain microbes.

Risk and Benefits 0f Phytoremediation

Benefits

Plant roots stabilize the soil and avoid the movement of contaminants by runoff and windy particles. Contaminants do not spread much via air and water. The method uses plants and natural resources and thus the cost is lower than other processes both in situ and ex situ. This is usually aesthetically pleasing and favored by the public compared to other structures and at the same time, it helps to clean the contaminated site. This technique makes it suitable for restoring agricultural soils affected by scattered industrial emissions. Also, it is an environment friendly method and multiple contaminants can be removed with the same plant. It is also possible to recover and reuse the valuable metals received from the process of phytomining. The plants can be easily monitored. Overall, this method is less harmful because it utilizes naturally occurring organisms and preserves the environment in a more natural state.

Risks

Phytoremediation cannot be used to tackle deep contamination; grasses can clean up to three feet, shrubs up to ten feet, and deep-rooted trees up to 20 feet. The cycle is usually slow and can take between three and five years to meet the planned clean-up goals. The toxicity of the contaminated land and the general condition of the soil may have some adverse effect on the plant. The choice of plants and their compositions is very much at the experimental stage and additional research is required. The method is highly dependent on local climatology and must be based on local criteria. In winter, the phytoremediation system can lose its effectiveness when plant growth slows down or stops. Also, large-scale operations can involve heavy agricultural machinery, which is usually located far from our polluted urban areas. Since wildlife and humans consume plants, measures must be taken to prevent the introduction of pollutants into the food chain. Finally, waste biomass must be disposed of correctly, often at high costs.

 

 

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Prospects

Plant biotechnological techniques have indeed performed an important role in the production of transgenic plants with enhanced potential for effective, clean, cheap and sustainable bioremediation technologies, still, many challenges remain such as,

  1. Regulatory constraints may be re-examined regularly to make the use of transgenic for phytoremediation less complicated.
  2. Insufficient information on the complex relationships that occur between the rhizosphere and the processes that are dependent on the ability of plants to absorb and extract metals from the contaminated setting.
  3. Phytoremediation techniques need to be designed with multiple genes stacked to satisfy the requirements of different sites.
  4. The use of transgenic plants in phytoremediation is still in field trials. Biosafety issues need to be adequately addressed and methods need to be established to avoid gene transfer to wild species.

Future of Phytoremediation

The effectiveness of phytoremediation also depends to a large degree on the plant’s ability to withstand the removal of contaminants. It is therefore of the highest concern to assess the maximum possible amount of xenobiotic compounds that can be produced and detoxified without damage, essential stress, and degradation of plant metabolism or redox processes in the organisms under consideration. Phytoremediation researches in the future may involve the elucidation of genetic, molecular, and cellular mechanisms to highlight how phytoremediation can be improved. PCR amplification and DNA fingerprint or microarray gene chip may provide a further overview of the process and may contribute to the selection of a particular plant variety to be applied to a specific pollutant within a built wetland or soil. The most important challenges and the improvement of phytotechnology efficiency rely on the dissemination of data, risk evaluation, public knowledge and acceptance of this green technology, as well as the advancement of coordination among scientists, industry, stakeholders, end-users, non-governmental organizations, and government agencies. This needs to be tackled to make sure that phytoremediation systems are effectively developed.

 

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Covid-19 Rethinking of traditional urban planning and mobility

Worldwide, the pandemic COVID-19 became the prime point of concern for the past few months Indeed, our liveability has been drastically affected and changed in these months. Cities, across the globe were the hard-hit areas by this pandemic; hence, it is important to understand the connection between city planning and spread of disease which is going to be the part and parcel of our daily life. Many are in the opinion that population density and dense urban morphology are the major contributors for the rapid spread of the virus.

If it’s going to like this, then how would we make the common places accessible and guarantee to build immunity and health? Whether active mobility could be a decisive factor in designing and reshaping the urban spaces? To address all these aspects, it is therefore important to consider cities in the intertwined perspective of people, economy and environment. Thus, this situation presents an opportunity and challenge to explore the new vistas of urban planning.

Pandemics in the past across the globe have reformed the planning, management and public health engineering systems of cities. Thus, kindle the introduction of modern civic amenities starting from urban sanitation systems, housing regulatory norms and etc. COVID-19 will not be an exception to that. This pandemic shows the indomitable connection with haphazard urbanisation on natural habitats, which left us on the brink to unknown pathogens that may originate from anywhere. Moreover, when the world is in favour of maintaining distance from each other as a precautionary measure, the ill of city density increase the vulnerability. However, on the positive side, the humongous advancements in digital revolution have allowed people to track the traverse of the virus flawlessly and could inform city planning and restructuring in the years to come.

The outbreak of COVID-19 has a thoughtful impact on transport sector and mode of mobility too. Countries and cities have imposed measures to restrict travel to limit the spread of the virus. Travel restrictions of public transport and employing physical distancing norms for commuters, yet to win the confidence of users and thereby remains difficult for psychological and behavioural reasons. On the other hand, we have seen, there is an improvement in air quality of many cities due to the limited transport activity, thus contributing to the achievements of number of Sustainable Development Goals (SDG). But these are short lived dividends and air pollution or emissions of toxic gases are expected to intensify again once the situation comes to normalcy. Hence, for long run, it would be prudent to plan and reshape cities based on active mobility and transport system.

The United Nations Economic and Social Commission for Asia and the Pacific (UNESCAP) enlisted different types of infrastructure to promote active mobility wherein, impetus was given to exclusive lanes earmarked for walking and cycling along with parks and resting areas. Subsequently, the connection between these infrastructure, active mobility and health could be used as a basis to build a resilient-city against future pandemics and extreme events. 

Steps ahead for a resilient future

This pandemic has highlighted couple of weaknesses of traditional urban planning approach and offers the possibility of reorienting mindset of transport, urban and city planners. Rather this pandemic has open debate about restructuring of cities and more importantly to look out for their response to future crisis. In fact, the cities should be plan not only resilient to deal with a pandemic but also to mitigate the worst effects of other extreme events.

Following are some of the key pointers on how urban planning could unfold in the years to come:

  • Urban agglomerations with multiple satellite towns could be the norm instead of conventional cities with a city centre;
  • Thrust should to be given upon ensuring and access to basic amenities viz. housing, water and healthcare facilities to all;
  • It is expected that there will be an additional 2.5 billion urban dwellers by 2050. So, formulation of laws and policies for improvement of informal settlements, access to affordable housing and healthy living conditions, should be other important prerequisites to be followed;
  • Integration of green-blue spaces and built infrastructure need to incorporate to build resilience, prevent natural disasters, hence leading towards climate change mitigation and environmental sustainability;
  • Overarching planning framework including economic, social, transport, and energy aspects should include to ensure that the ripple effects of local actions can be foreseen and controlled;
  • Introduction of digital infrastructure to support long-term planning through a data-driven approach.

This situation raises plethora of questions on the present way of life and put us to address and re-discover things which will perhaps lead to a more economic, social and environmentally friendly surrounding. Therefore, it is high time we resolute to adopt an ex-ante urban planning framework.

Sociological Relevance Of ‘New Normal’: Exploring New Social Norms And Practices

The pandemic crisis has brought forth a phase of ‘new normal’ which has presented before us a plethora of social norms and social practices. This ‘new normal’ imperative has brought about major transformation in different aspects of society in terms of physical distancing, social solidarity, understanding, coping and accommodating with the new social practice, impact on social isolation and marginalization of community, paradigm shift in social research, emphasis on ‘social health’ instead of ‘mental health’.

1. Physical Distancing and maintaining Social Solidarity: As Aristotle has proclaimed, ‘Man is a social animal’ and are unable to survive without social interaction, adjusting to this new norm of physical distancing has been difficult for humans (irrespective of gender). This new normal brought forth by the post-pandemic situation has initiated the issue of maintaining 2-metre distance with one another in order to avoid close contact which increases risk of diffusion of COVID 19. As Emile Durkhiem, one of the forefathers of sociology, rightly pointed out the importance of social solidarity in society, accommodating with such norm followed by physical distancing has also been challenging due to limited face-to-face interaction.

2. Understanding the new social norms and practices: “Social norms prescribe actions that produce socially beneficial outcomes, even when those actions have costs for individuals”. Shared beliefs about appropriate actions get reflected in social norms with the expectation that others will follow them. For example: Greeting each other has undergone a major change due to physical distancing caused by the spread of COVID 19. Nowadays, alternative greetings (non-verbal interaction) have come into existence which has taken the form of Namaste hand prayer (folding the hands together in prayer), elbow bump. Homeschooling or online classes has brought forth new practice of digital learning or digital education with the hindrance caused by Digital Divide!

3. Coping and Accommodating with new normal: This pandemic situation which has locked all of us in a Home ironically termed as ‘SAFE’ has been subjected to controversies due to the increasing Domestic Violence of women and men and elderly people. While on one hand, spending quality time with family has helped in maintaining the functionalist perspective, on the other hand, domestic abuse (irrespective of gender and age) has increased rampantly. Social stress coupled with financial insecurity has resulted in the significant rise in violence against men and women. There seems to be no other respite than coping and adjusting with the ‘abuse’ caused by new normal phase. The problem has been manifold for disabled children as well —— “a longing for adhering to a routine, rigidity in behavior which reduces the likelihood of an unanticipated event, and avoidance of situations where an outcome is indeterminate”. Most disabled children are suffering from anxiety related disorders due to the pandemic
crisis which continues to exist even during the post-pandemic phase.

4. Impact of social isolation (of patients) and marginalization of community: With the shortage of accommodation in hospitals and nursing homes, patients have also been advised to stay in home isolation which has increased the risk caused by marginalization from community. As reported in news channels, some neighbourhood community had ostracized patients residing in their community due to the phobia of being infected by the
disease. Such kind of social ignorance affects the psyche of the concerned patient and brings forth the issue of ‘Untouchability’ (caused by clinical casteism) and ‘social stigma’.

5. Paradigm shift in social research: The major challenge posed by the pandemic crisis and new normal happens to be in conducting social research. Sociologists and social researchers are being challenged by new norms of physical distancing since sociology deals mostly with primary data where social interaction plays a pivotal role. Due to the norm of physical distancing followed by covering of mask, free and viable interaction has become limited which has affected social research. Qualitative research, especially ethnography has become the major victim of the new norm which has resulted in a paradigm shift from face-to-face and free social interaction to a limited interaction with the suggested measures of distancing.

6. Social Health as the cynosure of new normal: The lockdown caused by the pandemic situation has also affected human psyche with problems like depression, anxiety related disorders, hypertension. Though these terms are mostly psychological, yet sociologists perceive them through their perspective of social health. Any kind of mental disorder is always caused by the hegemonic social norms or social situation in which the concerned
person is situated. Such emphasis on social health has been due to social factors like marginalization from family and community, social stigma which has resulted in depression and other mental health related disorders.

With such steeping rise in new social norms and practices with the onset of ‘new normal’, society is also undergoing social transformation with its positive and negative implications in one’s everyday life. The challenge ahead for sociologists is to recognize the ways to limit ‘social interaction’ and also how to ‘de-familiarize the familiar’ as social beings!!

REFERENCES:
Gupta, Achala & Chadd, Katie, Experiencing the ‘new Normal’: Sociology of COVID 19 (Pandemic) from a Disability perspective, April 2020,
https://discoversociety.org/2020/04/06/experiencing-the-new-normal-sociology-of-covid-19-pandemic-from-a-disability-perspective/ 

Mishagina, Natalia, The importance of new social norms in a COVID 19 outbreak, March 2020, https://policyoptions.irpp.org/magazines/march-2020/the-importance-of-new-social-norms-in-acovid-
19-outbreak/ 

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